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Following electroporation-mediated transfer into Bifidobacterium , the resulting engineered strain specifically colonized tumors in a rat xenograft model and expressed the cytosine deaminase enzyme, which converted the 5-fluorocytosine into the cytotoxic agent 5-fluorouracil, inducing tumor cell apoptosis and regression
Watson CJ, Whitledge JD, Siani AM, Burns MM
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